Our research goal on big data management and analytics is to address the research challenges for delivering effective, scalable and high performance software systems for managing, querying and mining complex big data at multiple dimensions, including 2D and 3D spatial and imaging data, temporal data, spatial-temporal data, and sequencing data. Our research goal on biomedical informatics is to develop novel methods and software systems to optimize the acquisition, extraction, management, and mining of biomedical data with much improved efficiency, interoperability, accuracy, and usability to support biomedical research and the healthcare enterprise.